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Author

A. Miserez

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Oct 2026

Peptide Coacervates with Cathepsin B-Triggered Intracellular Cargo Release

Understanding the molecular grammar of liquid–liquid phase separation has enabled rational design of peptide coacervates as intracellular therapeutic carriers with tunable viscoelasticity, controlled cargo partitioning, and enhanced cellular uptake. However, sequence-level determinants governing coacervate disassembl...

Pooja Sharma, Soheil Haddadzadegan, M. Ghafouri et al. · 0 citations
Open access Jul 2026

Single-molecule mass measurements uncover shifting RNA interactions during condensate phase transitions

It is demonstrated that single-molecule mass measurements with mass photometry can capture RNA-protein interactions in phase-separated protein systems and can distinguish between charge neutralization, which drives coacervation, and complex formation, which mediates phase re-entry, making it a highly complementary tool...

Axel Leppert, Jesper Shiapan, Irena Papageorgiou et al. · 0 citations

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