Open access
Nov 2026
spOT-NMF: gene expression deconvolution via optimal transport with proximity-aware niche mapping for spatial transcriptomics
Abstract Spatial transcriptomics enables direct profiling of cellular organization within intact tissues, yet two challenges limit its full exploitation: accurate reference-free deconvolution of mixed expression signals (including species-admixed models such as xenografts), and lack of tools that can translate per-spot...
Aly O. Abdelkareem, Gurveer S. Gill, V. Manoharan et al.
· Briefings in Bioinformatics · 0 citations