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A. Muotri

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Open access Oct 2026

Single‐Cell Integration of Mouse Models of Autism Reveals Conserved Transcriptomic Signatures of Excitatory‐Inhibitory Imbalance and Glial Dysfunction

ABSTRACT The etiological heterogeneity of autism spectrum disorder (ASD) complicates identifying core molecular mechanisms. We systematically integrated scRNA‐seq data from 11 diverse genetic and environmental mouse ( Mus musculus ) models, encompassing > 300,000 cells across multiple brain regions and developmental st...

J. Nani, Victor J. Duque, A. Muotri et al. · 0 citations
Open access Aug 2026

Corticothalamic assembloids recapitulate human fetal brain morphologies and enhance neuronal complexity.

This work makes an initial effort in describing the diversity of neuronal morphology in human neural organoids and assembloids, and establishes structural phenotyping as a critical dimension for validating human neural models and underscores their value for modeling morphofunctional disorders.

André Saraiva Leão Marcelo Antunes, Maria Carolina Pedro Athié, Ana C. Caznok Silveira et al. · 1 citation

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