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Author

Á. Narbona-Pérez

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Open access Sep 2026

Tirzepatide preserves hematopoietic stem and progenitor cycling while remodeling inflammatory monocytes in obese mice

Obesity expands myeloid progenitors, myelopoiesis and increases the production of monocytes. While weight loss (WL) alleviates aspects of this inflammatory dysregulation, it is not known whether GLP-1 receptor agonists or other traditional modalities of WL differentially modify hematopoietic stem/progenitor cells (HSPC...

N. Krah, Elena Gonzalez-Alvarado, Amog P. Urs et al. · 0 citations
Open access Aug 2026

Sequence adaptations satisfy the constraints of mitochondrial membrane protein evolution

Inner mitochondrial membrane proteins must be sufficiently hydrophilic to withstand aqueous exposure during translation and transit to the mitochondria. Meanwhile, their transmembrane segments must be sufficiently hydrophobic to stably embed in the lipid membrane. We hypothesized that sequence-level adaptations evolved...

Tarun Yadav, Jonathan Borowsky, Á. Narbona-Pérez et al. · 0 citations

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