Open access
Aug 2026
ACKR1-expressing venous endothelial cells establish a pro-fibrotic niche in pulmonary fibrosis
In vitro co-culture assays using ACKR1+ VECs isolated from IPF lungs demonstrate that these cells drive myeloid recruitment and fibroblast activation through ACKR1 dependent mechanisms and show that pharmacologic inhibition of ACKR1 attenuates experimental lung fibrosis.
K. Kontodimas, A. Raslan, Benjamin Spira et al.
· bioRxiv · 0 citations