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A. Neumann

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Open access Sep 2026

826. Polygenic liability to psychiatric disorders predicts depressive and anxiety symptoms across pregnancy and postpartum

Abstract Background Pregnancy and the postpartum period constitute a high-risk window for the emergence of depressive symptoms. Peripartum depression (PPD) affects around 17% of women worldwide [1] and remains substantially underdetected, with clinically meaningful consequences for maternal functioning, mother-infant b...

B. Vai, L. Fortaner-Uyà, M. Shahisavandi et al. · 0 citations
Open access Sep 2026

Genome-wide analysis of social behaviour across social domains, reporters and developmental stages: a meta-regression approach.

Social behaviour is a heritable trait linked to well-being and mental health, yet it varies across social context, including social domains, informants and development, which may shape its underlying genomic architecture. Here, we conducted a genome-wide meta-regression meta-analysis of social behaviour from infancy to...

L. de Hoyos, Fenja Schlag, Sanjeevan Jahagirdar et al. · 0 citations
Review Aug 2026

Methylation profile scores in child and adolescent health: a practical guide.

Most MPSs are better characterised as research tools at an early stage of development rather than clinical tools, and are highlighted as research tools at an early stage of development rather than clinical tools.

I. Schuurmans, S. Defina, A. P. C. Hermans et al. · 0 citations
Open access Jul 2026

DNA methylation as proxy of genetic, prenatal and perinatal psychiatric risk factors

Background. Cord blood DNA methylation profile scores (MPSs) based on genetic and pre-/perinatal risk factors for neurodevelopmental conditions (NDCs) may capture downstream biological effects and help understand how combined exposure signals contribute to NDC risk. Methods. Using data from two longitudinal birth cohor...

Elena Isaevska, Rosa H. Mulder, I. Schuurmans et al. · 0 citations
Open access Aug 2026

The prenatal exposome and genome in predictive modelling of DNA methylation

It is found that genomic associations with cord blood DNAm are stronger and more widespread than prenatal exposures, although typically, the prenatal exposome explains additional variation in DNAm beyond genetic influences.

Rosa H. Mulder, Elena Isaevska, C. Cappadona et al. · 0 citations

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