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A. Nicolaides

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Review Open access Oct 2026

Coherence, transformation, and breakdown in living systems: part I — the common higher-order regulatory architecture (CHORA) hypothesis

The coherence of living systems extends beyond the lifespan of the individual organism: it persists across biological lineages, through the turnover of organisms and change across deep evolutionary time. This paper terms this phenomenon evolutionary coherence, the lineage-scale expression of a more general property, bi...

A. Nicolaides · 0 citations

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