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Author

A. Ogara

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Open access Sep 2026

Evaluation of the gastroprotective mechanisms of the ethanol leaves extract of Jatropha multifida in ethanol-induced gastric ulceration in Wistar rats: Integrated in Vivo, biochemical, and in silico study

Peptic ulcer disease (PUD) results from an imbalance between aggressive factors and mucosal defense mechanisms, with oxidative stress and prostaglandin depletion playing central roles in peptic ulcerations. This study investigated the gastroprotective potential and mechanistic pathways of the ethanol extract of Jatroph...

Tochukwu R. Eze, I. Orhonigbe, Isioma C. Okonta et al. · 0 citations
Open access 2025

Formulation and Physicochemical Characterization of ChitosanCoated Simvastatin Nanoparticles

The combined findings indicate that chitosan coating improved the physicochemical characteristics of simvastatin while providing sustained release potential, and chitosan-coated simvastatin nanoparticles represent a promising oral nanocarrier system for enhancing simvastatin delivery and therapeutic performance.

V. Ozougwu, Bartholomew O. Okolo, A. Ogara · 0 citations

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