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Author

A. Ottaiano

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Jul 2026

Non-invasive cell-free DNA-based approach for the diagnosis of aneuploidies in spontaneous abortion.

OBJECTIVE Spontaneous abortion is the most common complication in early pregnancy, with chromosomal abnormalities accounting for up to 50% of first-trimester losses. Conventional genetic analyses often rely on invasive procedures that may be limited by technical challenges and patient reluctance. This study aimed to ev...

Giovanni Savarese, M. Guida, Monica Ianniello et al. · 0 citations
Review Open access Aug 2026

PIK3CA in Cancer: Structure, Biology, Alterations, and Actionability

This review provides a comprehensive, updated, and comparative overview of PIK3CA biology, its molecular alterations across human cancers, their prognostic and therapeutic relevance, and the current development of treatments targeting the pathway activated by PIK3CA.

A. Ottaiano, C. Picone, M. Santorsola et al. · 0 citations

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