A. P. Camargo

“Quadrupling” the protein family space with global metagenomics

The known universe of protein families represents only a small fraction of nature’s molecular diversity. From 40.3 billion sequences across 40,446 metagenomes, 9,540 metatranscriptomes, and 539 million proteins from 167,415 reference genomes, we identified 608,258 previously uncharacterized protein families with ≥100 m...