The results show a large overlap of the genetic makeup associated with functional connectivity across brain networks but also identify network specific signals, suggesting a potential genetic stratification between cognitive and sensory-motor networks.
X. Caseras, T. Chambers, L. Hall et al.· Nature Communications· 0 citations
Despite great progress on case–control polygenic prediction, an unmet need remains for a method that genetically distinguishes clinically related disorders (e.g., schizophrenia (SCZ) versus bipolar disorder (BIP) versus major depressive disorder (MDD) versus controls). We introduce differential diagnosis–polygenic risk...
W. Peyrot, G. Panagiotaropoulou, L. O. Olde Loohuis et al.· Nature Genetics· 0 citations
There is promise in pathway-level and multi-omics approaches to elucidate biologically meaningful heterogeneity within SSD and support for synaptic mechanisms as potential targets for understanding and stratifying treatment-resistance is provided.
P. B. Leung, K. C. Wong, S. Smart et al.· medRxiv· 0 citations
Case-Case GWAS is used to identify common genetic variants differentially associated with schizophrenia and bipolar disorder, analysing 67,390 schizophrenia cases and 41,917 bipolar disorder cases and demonstrating that genuine divergent genetic effects exist beyond the substantial shared liability.
I. Willcocks, A. Richards, S. Legge et al.· medRxiv· 0 citations
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