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Author

A. Pavlopoulou

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Open access Sep 2026

Network-guided identification and multi-targeting of cell cycle regulatory hubs in obesity-linked colorectal cancer

Purpose: Obesity-associated colorectal cancer (CRC) involves complex molecular networks that limit the effectiveness of single-target therapies. This study aimed to develop an integrative computational pipeline for identifying key regulatory hubs and designing a multi-target-directed ligand (MTDL) capable of simultaneo...

Merve Uça Apaydın, Huseyin Guner, Resat Unal et al. · 0 citations
Open access Aug 2026

Comprehensive Analyses of SOX7 Provide Novel Insights on Its Tumor Suppressor Role and Its Target Genes with Therapeutic Implications in Multiple Myeloma

Results indicate that SOX7 functions as a tumor suppressor in MM, and its inactivation promotes cell cycle progression, and the anti-myeloma effects of panobinostat in MM.1S cells may be partially mediated through SOX7 induction.

Arda Ceylan, Xiao-Zhou Hu, Tevfik Hatipoğlu et al. · 0 citations

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