Author

A. Pavlova

2 papers indexed here

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Open access Sep 2026

Modified crRNA variants for precise targeting of point mutations in human mitochondrial DNA by CRISPR-Cas12a

The CRISPR-Cas12a system, primarily used for nuclear genome editing, operates through RNA-guided cleavage of target DNA. Given the high copy number of mitochondrial DNA (mtDNA) in cells and the pathogenic potential of mtDNA mutations, there is substantial interest in developing methods to selectively eliminate mutant m...

N. Shebanov, Anne-Marie Heckel, Natalia Nikitchina et al. · bioRxiv · 0 citations

Open access Sep 2026

Synthesis and In Vitro Biological Evaluation of Amphiphilic Derivatives of Carvacrol as Potent Antibacterial Agents

Background/Objectives: The rapid emergence and spread of antibiotic-resistant bacterial strains represent a major global health threat, requiring the development of novel broad-spectrum antimicrobial agents. This study aims to design, synthesize, and evaluate a novel series of multitarget amphiphilic carvacrol derivati...

D. Zadvornykh, Mei-Ling Wang, A. Bardasheva et al. · Antibiotics · 0 citations