Author

A. Peer-Zada

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Review Open access Oct 2026

Genomic Landscape and Clinical Predictors of Germline Variants in Pediatric CNS Tumors in a Highly Consanguineous Population

Due to high consanguinity, pediatric central nervous system (CNS) tumors in Saudi Arabia are increasingly recognized as manifestations of cancer predisposition syndromes (CPS). This study evaluates the diagnostic yield and clinical correlations of comprehensive germline profiling in this population. A 10-y...

Nahla Mobarak, Aziza Mushiba, Murtda ALsultan et al. · Neuro-Oncology Pediatrics · 0 citations

Open access Sep 2026

Novel juxtamembrane FLT3 in-frame insertion in a child with refractory AML: a case report of durable remission following allogeneic HSCT and FLT3 inhibitor therapy

FLT3 gene mutations, particularly internal tandem duplications ( FLT3 -ITD), are present in approximately 25%–30% of patients with acute myeloid leukemia (AML) and are important drivers of leukemogenesis; less frequently, FLT3 mutations occur as tyrosine kinase domain (TKD) variants. Non-canonical variants,...

A. Peer-Zada, Mohammed Al-Rimawi, Farah Malaeb et al. · Frontiers in Oncology · 0 citations