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Author

A. Peñarroya

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Open access Aug 2026

Replicative history as a major determinant of epigenetic noise across human tissues

DNA methylation changes accumulate with age through both regulated and stochastic processes, yet the determinants of epigenetic information loss remain poorly defined. Using genome-wide DNA methylation profiles from 1,531 healthy human samples spanning 14 tissues, we quantified epigenetic noise by Shannon entropy and c...

A. Peñarroya, J. J. Alba-Linares, R. F. Pérez et al. · 0 citations

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