Open access
Oct 2026
NF-κB–mediated chemoresistance emerges from distorted fallopian tube cell-state trajectory in ovarian cancer
Homeostatic gene expression programs persist through oncogenesis, creating new malignant states that adapt to therapies. To reveal how fallopian tube epithelia (FTE) cell states transform into intra-tumoral heterogeneity in ovarian high-grade serous carcinoma (HGSC), we analysed treatment-naive tumors ( n = 50)...
A. Pirttikoski, Shabnaz Koochakkhani, Laura Gall-Mas et al.
· Cell Death Discovery · 0 citations