A Quantitative Assessment of MRI-Visible Perivascular-Space Burden Across the Cognitive Spectrum: Associations with APOE ε4 Status and Venous Sinus Volume
The findings of this cross-sectional observational MRI study support further study of venous sinus morphology as a potential contributor to MRI-visible PVS burden, while longitudinal and flow-sensitive studies are needed to clarify causality and glymphatic clearance mechanisms.