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Author

A. Pyle

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Open access Aug 2026

Heteromeric LGP2-MDA5 receptor complexes drive antiviral signaling

The innate immune receptor MDA5 serves as a first line of defense against RNA viruses by recognizing viral double-stranded RNA (dsRNA) and initiating antiviral signaling. MDA5 is upregulated by another RLR family member known as LGP2, which has been proposed to enhance MDA5 activity by recruiting MDA5 to dsRNA. However...

Gina Buchel, Ling Xu, A. Pyle · 0 citations
Open access Sep 2026

Ebola virus mRNAs contain RNA structures that are critical for viral infection and targetable by antisense oligonucleotides

The first in-cell secondary structure maps of four EBOV mRNAs are presented, finding that structure content is concentrated within protein coding regions, resembling the highly structured genomes of positive-sense RNA viruses, while untranslated regions are relatively unstructured.

Michelle Luo, J. Olejnik, K. Meier et al. · 0 citations

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