Squaramides are well-known charge-neutral bioisosteres of many nitrogenous functional groups, including those found in the side chains of amino acids (e.g., Arg, Asn, Glu, and Lys). However, there are very few reports of squaramide-functionalisation of these side chains. Herein, we report a convenient three-step synthe...
Kylie A. Agnew-Francis, Rachel M. Chen, A. Robertson· RSC Advances· 0 citations
Background Pro-inflammatory caspase-1 is a key player in innate immunity. Physiological activation of the inflammasome/caspase-1 pathway supports host defense against pathogens, whereas dysregulated activation contributes to the pathogenesis of neonatal diseases such as bronchopulmonary dysplasia. Although preterm infan...
Hannah Siedel, Kristin Hieronymus, Jan M. Niehues et al.· Frontiers in Pediatrics· 0 citations
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