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Open access Sep 2026

Localized disruption of the presynaptic endoplasmic reticulum in Atlastin mutants.

The endoplasmic reticulum (ER) extends throughout neurons and regulates many functions, including neurite outgrowth, neurotransmission, and synaptic plasticity. Mutations in ER-shaping proteins cause the neurodegenerative disorder Hereditary Spastic Paraplegia (HSP), yet the ultrastructure and dynamics of neuronal ER r...

Mónica C. Quiñones-Frías, Dina M. Ocken, A. Rodal · 0 citations
Open access Aug 2026

Dynamin proline-rich domain isoform abundance, not identity, determines synaptic vesicle recycling efficiency in Drosophila

During neurotransmission, synaptic vesicle exocytosis adds membrane and proteins to the cell surface. To sustain further release, this material must be retrieved, via several distinct endocytic modes matched to the level of exocytosis. The GTPase dynamin plays a central role in endocytosis, but it has remained unclear...

A. M. Silveira, Kevin M. De León González, Amy L Scalera et al. · 0 citations

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