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Author

A. Ruiz

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Sep 2026

A single-center open-label, randomized, parallel-group controlled clinical trial on the long-term effect of the treatment with EGb 761 in blood markers of inflammation and neurodegeneration in patients with mild cognitive impairment: ACE-2020-EGb 761.

BackgroundNeuroinflammation plays a central role in Alzheimer's disease (AD) pathology and other dementias. EGb 761, a standardized Ginkgo biloba extract, has shown potential anti-inflammatory and neuroprotective properties.ObjectiveThis study evaluated the effects of EGb 761 on plasma proteins related to inflammation...

X. Morató, M. Marquié, J. Tartari et al. · 0 citations
Open access Sep 2026

Schizophrenia-associated polygenic liability and structural genomic risk demonstrate broadly distributed neuropsychiatric associations in the All of Us Research Program

Background: Schizophrenia liability reflects both the aggregate effects of many common genetic variants and rare structural variation at recurrent neurodevelopmental copy-number variant (ND-CNV) loci. Although both components of genetic liability have been associated with schizophrenia and related phenotypes, it remain...

Anne Marie Wells, An-Nie Dang, A. Ruiz · 0 citations
Open access Aug 2026

Predictive value of the Alzheimer polygenic risk score on cognitive decline in patients with mild cognitive impairment and Alzheimer's disease dementia

Although polygenic burden contributes to variability in cognitive trajectories, its added predictive value beyond routinely available clinical variables remains modest.

B. Calm, Adrián Hinojosa-Calleja, F. García-Gutiérrez et al. · 0 citations
Open access Sep 2026

Pleiotropic and Distributed Neuropsychiatric Effects of Neurodevelopmental Copy Number Variants in the All of Us Biobank

These findings provide empirical support for a distributed model of ND-CNV-associated neuropsychiatric liability in which numerous modest, directionally concordant phenotype associations collectively contribute to pleiotropic risk across neuropsychiatric domains.

Anne Marie Wells, Fei-Yang Zhao, Sudha Seshadri et al. · 0 citations
Open access Aug 2026

Alzheimer’s disease polygenic risk score associates with hippocampal subfield atrophy and immune-related genetic mechanism

Specific AD-SNPs enriched in immune-brain axis pathways rather than Aβ related processes, were associated with reduced volumes of CA1 and subiculum prior to dementia onset, which supports that AD-PRS may capture genetic susceptibility to concomitant neurodegenerative diseases frequently misdiagnosed as AD.

C. Olivé, I. de Rojas, Linda Zhang et al. · 0 citations

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