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A. S. Silva

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Open access Aug 2026

Evolutionary implications of phenotype switching for growth and survival of tumors in stochastic environments

A mathematical model of tumor growth under fluctuating conditions with stochastic phenotypic epithelial-mesenchymal switch as the main mechanism of adaptation is developed, and non-trivial evolutionary outcomes are revealed, depending on the relative time scales of the underlying processes.

Sanasar G. Babajanyan, Yuri I. Wolf, R. Canevarolo et al. · 0 citations
Open access Jul 2026

Fluctuating environment causes neoplastic transition and epithelial-mesenchymal plasticity in human cells

The immortalized non-tumorigenic breast epithelial cell line (MCF10A) develops neoplastic clones under fluctuating conditions in-vitro that mimic the harsh tumor microenvironment and is identified as a potential therapeutic target against epithelial-mesenchymal plasticity and metastatic spread in breast cancer.

Erez Persi, Rafael R. Canevarolo, P. Sudalagunta et al. · 1 citation