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Author

A. Salis

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Open access Sep 2026

Binding Does Not Mean Stabilizing: High-Affinity Porphyrins Exhibit Opposite Effects on G‑Quadruplex Stability

Binding affinity is often used as a predictor of G-quadruplex (G4) stabilization. Here, we show that ligand binding and quadruplex stabilization can be thermodynamically decoupled. Two closely related tetracationic porphyrins bind the human telomeric G4 with comparable affinities approaching 106 M–1 but induce opposite...

Cristina Carucci, Monica Mura, Francesca Cherchi et al. · 0 citations
Review Open access Sep 2026

In-electrode faraday cage-type biosensors: Enclosing biorecognition for ultra-sensitive electrochemical and electrochemiluminescence detection.

Electrochemiluminescence (ECL) and electrochemical biosensors traditionally rely on on-electrode, sandwich-type architectures in which only a small fraction of immobilized labels resides within the electrochemically active region, fundamentally limiting sensitivity. In recent years, a new class of Faraday-cage-type (FC...

Nastaran Arab, A. Salis, Morteza Hosseini et al. · 0 citations

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