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Open access Aug 2026

Multiscale mechanistic modeling for the rational design of novel dual-target candidates against acetylcholinesterase and NADPH oxidase: an advanced computational study

Introduction Alzheimer’s disease is a complex neurodegenerative illness strongly associated with oxidative stress, which requires immediate intervention for therapeutic agents with potent antioxidant properties. Methods In this work, novel derivatives based on benzofuran and pyrazole scaffolds were designed and assesse...

Mohamed El Fadili, M. Er-rajy, S. Mujwar et al. · 0 citations
Open access Sep 2026

Repositioning antiviral phytoconstituents as broad-spectrum inhibitors of influenza A neuraminidase and human metapneumovirus fusion protein

Viral respiratory infections still exist as a major global health concern. Influenza A viruses and human metapneumoviruses are among the main pathogens responsible for infections that can progress to severe acute respiratory forms. Despite the availability of certain therapeutic options, the need for effective treatmen...

N. Mounadi, H. Nour, M. el Kouali et al. · 0 citations

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