Open access
Jul 2026
L-2-Hydroxyglutarate sensitizes ferroptosis through ATF3/CHAC1-mediated glutathione degradation in hepatocellular carcinoma
The L2HGDH-L2HG axis is identified as a previously unrecognized metabolic checkpoint controlling ferroptosis sensitivity in liver cancer and glutathione degradation is uncovers as a therapeutically exploitable vulnerability for ferroptosis-based treatment strategies in HCC.
Cai-Xia Xi, Jun-Feng Pang, Mohammad Oliaeimotlagh et al.
· Cell Death and Disease · 1 citation