Open access
Nov 2026
Early hyperactivation and activation-associated mitochondrial abnormalities in GATA2 deficiency
Germline GATA2 deficiency is a hereditary disorder characterized by immunodeficiency, bone marrow failure, and a high risk of myelodysplastic neoplasms and acute myeloid leukemia (AML). Although abnormalities of innate immunity are well recognized, the phenotype and functional state of CD8 + T cells remain inco...
Marta Penco, M. Capelletti, Lorenzo Manfreda et al.
· Frontiers in Immunology · 0 citations