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A. Schober

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Open access Jul 2026

Reassessing Tcf21-iCre for Adult Cardiac Fibroblast Gene Deletion: Limited Recombination Efficiency Following Tamoxifen Injections

Highlights What are the main findings? Tcf21-iCre demonstrates minimal recombination efficiency in adult cardiac fibroblasts after tamoxifen injection, with mono-allelic events indicating low Cre activity. Neither pro-fibrotic stress nor additional tamoxifen dosing improves recombination efficiency. What are the implic...

A. Schober, Lukas Müller, R. Wardman et al. · 0 citations

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