Author

A. Senabouth

2 papers indexed here

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Open access Oct 2026

Genetic variants shape single-cell chromatin accessibility and disease risk.

Understanding how genetic variation shapes gene regulation at single-cell resolution is crucial for elucidating complex disease mechanisms1, but has been limited by the lack of large-scale single-cell multi-omics data2-4. Here we present single-cell assay for transposase-accessible chromatin with sequencing of 3.5 mill...

A. Xue, Jia-Nan Fan, Oscar A. Dong et al. · Nature · 3 citations

Open access May 2024

Genetic variants associated with cell-type-specific intra-individual gene expression variability reveal new mechanisms of genome regulation

Gene expression levels can vary substantially across cells, even in a seemingly homogeneous cell population. Identifying the relationships between genetic variation and gene expression is critical for understanding the mechanisms of genome regulation. However, the genetic control of gene expression variability among th...

A. Xue, S. Yazar, José Alquicira-Hernández et al. · bioRxiv · 1 citation