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Author

A. Sharma

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Open access Aug 2026

Spindle Assembly Checkpoint Competency Determines Sensitivity to KIF18A Inhibition in Small Cell Lung Cancer

This study provides the first mechanistic characterization of KIF18A dependency in SCLC, identifying SAC competency as the primary determinant of response, and establishes a biologically informed framework for patient stratification and rational combination strategies.

Chiori Tabe, Rajesh Kumar, Yue Huang et al. · 0 citations
Open access Jul 2026

Spindle Assembly Checkpoint Competency Determines Sensitivity to KIF18A Inhibition in Small-Cell Lung Cancer

This study provides the first mechanistic characterization of KIF18A dependency in SCLC, identifying SAC competency as the primary determinant of response and establishes a biologically informed framework for patient stratification and rational combination strategies relevant to ongoing KIF18A inhibitor clinical trials...

Chiori Tabe, Rajesh Kumar, Yue Huang et al. · 0 citations

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