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Author

A. Shilatifard

3 papers indexed here

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Open access Oct 2026

SETDB1 preferentially silences evolutionarily young retroelements.

Long-read RNA sequencing mapped to a telomere-to-telomere mouse genome assembly is used to resolve the specific contributions of SETDB1 to TE silencing at single-locus resolution and provide a framework for dissecting how chromatin-based mechanisms cooperate to maintain subclass-selective TE repression.

Bercin K. Cenik, Si-Mai Wang, Marta Iwanaszko et al. · 0 citations
Open access Sep 2026

POU2AF2/OCA-T1 coactivates POU2F2 and defines a lineage-specific dependency in diffuse large B-cell lymphoma

Lineage-restricted transcriptional programs establish cell identity and can create selective dependencies in cancer. Here, we identify POU2AF2, encoding the transcriptional co-activator OCA-T1, as a critical lineage-specific dependency in a subset of diffuse large B-cell lymphoma (DLBCL). Pan-cancer dependency analyses...

Rima Tulaiha, Liam Shanley, Amanda Luvisotto et al. · 0 citations
Review Aug 2026

Transcriptional kinases drive gene expression network plasticity.

This work highlights non-canonical transcriptional kinases that could operate alongside and beyond CDKs to modulate transcription by RNAPII, and discusses how these kinases could introduce context-specific CTD modifications that enable transcriptional plasticity, facilitate rapid loci-specific activation, and integrate...

David D. Lowe, A. Shilatifard · 0 citations

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