Long-read RNA sequencing mapped to a telomere-to-telomere mouse genome assembly is used to resolve the specific contributions of SETDB1 to TE silencing at single-locus resolution and provide a framework for dissecting how chromatin-based mechanisms cooperate to maintain subclass-selective TE repression.
Bercin K. Cenik, Si-Mai Wang, Marta Iwanaszko et al.· Proceedings of the National...· 0 citations
Lineage-restricted transcriptional programs establish cell identity and can create selective dependencies in cancer. Here, we identify POU2AF2, encoding the transcriptional co-activator OCA-T1, as a critical lineage-specific dependency in a subset of diffuse large B-cell lymphoma (DLBCL). Pan-cancer dependency analyses...
Rima Tulaiha, Liam Shanley, Amanda Luvisotto et al.· bioRxiv· 0 citations
This work highlights non-canonical transcriptional kinases that could operate alongside and beyond CDKs to modulate transcription by RNAPII, and discusses how these kinases could introduce context-specific CTD modifications that enable transcriptional plasticity, facilitate rapid loci-specific activation, and integrate...
David D. Lowe, A. Shilatifard· Molecules and Cells· 0 citations
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