Open access
Aug 2026
Myeloid-derived MIF is a central regulator of MDSC-driven T-cell dysfunction in head and neck squamous cell carcinoma
These findings identify myeloid-derived MIF as a central regulator of the MDSC–Treg–CD8⁺ axis in HNSCC and support myeloid-targeted MIF inhibition as a strategy to reprogram the TME and enhance responses to immune checkpoint blockade.
Suvekshya Shrestha, F. Lamenza, Natalie Kazmierowicz et al.
· Oncoimmunology · 0 citations