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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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A. Simon

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Open access Sep 2026

Skeletal pathologies caused by PLS3 inactivation are predominantly associated with impaired cortical bone integrity.

The identification of pathogenic PLS3 variants in individuals with X-linked osteoporosis (XLO) has demonstrated the importance of the actin-bundling protein plastin-3 for skeletal integrity. We and others have previously reported that Pls3-deficient mice display a skeletal phenotype that unexpectedly affects only the c...

O. Windels, A. Simon, Lara Schiewek et al. · 0 citations

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