INTRODUCTION
Neurodegenerative disorders, including Alzheimer's, Parkinson's, Huntington's disease, and amyotrophic lateral sclerosis, remain difficult to treat because the Blood-brain Barrier (BBB) severely restricts therapeutic access to the central nervous system. This review evaluates BBB biology and the potential...
A. Singh, Shatrudhan Prajapati, Shikha Yadav et al.· Current Neurovascular Resear...· 0 citations
Dementia is a progressive, neurodegenerative disease that involves a
gradual loss of functions of the brain, such as memory, reasoning, and attention. This review
will assess the association between Artificial Intelligence (AI) technologies and the pharmacological
treatment of dementia for diagnosis and treatment....
Namrata Bhadauria, A. Singh, Niranjan Kaushik et al.· Current Signal Transduction...· 0 citations
Small interfering RNA (siRNA) and messenger RNA (mRNA) therapeutics represent transformative approaches in precision pharmacology, enabling targeted gene silencing and protein expression, respectively. This review provides a comprehensive analysis of their molecular mechanisms, delivery strategies, clinical application...
Ritu Dahiya, A. Singh, Pooja Mathur et al.· Current Gene Therapy· 0 citations
Non-Small Cell Lung Cancer (NSCLC) remains a major clinical challenge
and is one of the leading causes of cancer-related mortality worldwide. Its poor prognosis is driven
by substantial molecular heterogeneity, dynamic interactions between tumor cells and the surrounding
microenvironment, and the frequent developme...
Shatrudhan Prajapati, Shabana Khatoon, A. Singh et al.· Current Enzyme Inhibition· 0 citations
Neurodegenerative disorders (NDDs) such as Alzheimer's, Parkinsons etc., are progressive and debilitating conditions that have little therapeutic intervention. Existing pharmacological interventions mainly provide symptomatic relief and do not respond to the pathophysiology of these diseases, which is complex and multi...
Shatrudhan Prajapati, Shikha Yadav, A. Singh et al.· Current Pharmaceutical Biote...· 0 citations
Breast cancer is also one of the most common causes of cancerrelated
deaths in the world, and this is mainly because of the therapeutic resistance and
immune evasion mechanisms in the tumor microenvironment. An immunosuppressive
tumor microenvironment, characterized by dysfunctional immune cells and stromal impedim...
A. Singh, Shatrudhan Prajapati, Shikha Yadav et al.· Current Pharmacogenomics and...· 0 citations
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