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Review Open access Sep 2026

Longitudinal associations of rest-activity rhythms with executive function, plasma biomarkers, and clinical outcomes in older adults

Introduction Daily patterns of activity, rest, and sleep, referred to as rest–activity rhythms (RARs), can be characterized by their day-to-day regularity, within-day fragmentation, and contrast between active and rest periods across the 24-h cycle. Disruptions (e.g., irregular schedules, fragmented activity, or reduce...

Daniel D. Callow, Nisha Rani, A. Spira et al. · 0 citations
Open access Sep 2026

Plasma inflammatory markers and brain white matter microstructure in late middle-aged and older adults.

Higher levels of peripheral pro-inflammatory markers are associated with white matter microstructure associated with multi-shell dMRI Neurite Orientation Dispersion and Density Imaging (NODDI), supporting the sensitivity of these dMRI-based metrics to inflammatory processes.

Siona Mishra, C. Pettigrew, Chidi Ugonna et al. · 0 citations
Open access Aug 2026

Association of Psychosocial Stress with Altered Functional Connectivity of Large-Scale Brain Networks in Aging Adults

Although evidence suggests that psychosocial stress is a risk factor for cognitive decline in aging adults, potential mechanisms for this association are not well understood. This cross-sectional study examined associations of two measures of self-reported psychosocial stress, including the perceived stress scale (PSS)...

G. Pfaff, E. Paitel, A. Soldan et al. · 0 citations

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