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A. Stevaert

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Sep 2026

6-Substituted 7-Deazapurine Ribonucleosides Capable of Non-canonical Base Recognition as Inhibitors of Respiratory RNA Viruses

Sub-micromolar potency was observed for multiple compounds, with minimal cytotoxicity and inhibition of host DNA polymerases, suggesting that despite lacking a hydrogen-bond donor, analogues with either 6-alkyl or 6-alkynyl substituents likely engage polymerases through distinct recognition mechanisms.

Elisabetta Groaz, Zi-Hua Zheng, Brett L. Hurst et al. · 0 citations

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