Design of some β-lactam derivatives as prospective antibacterial agents: Synthesis, characterization, computational analysis, and molecular docking studies
A series of substituted β-lactam derivatives (3a–e) were synthesized via Schiff base intermediates using a Staudinger [2+2] cycloaddition reaction and characterized by FT-IR and 1H NMR spectroscopy. DFT calculations (B3LYP/6-31G(d)) were performed to investigate molecular geometry, electronic properties, and reactivity...