Author

A. Szóstek-Mioduchowska

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Open access Sep 2026

The effect of macrophage secretome on equine endometrial fibroblast transcriptomic and functional characteristics.

Endometrial fibrosis is a main hallmark of endometrosis, a degenerative condition of the equine endometrium. Fibrosis, is characterized by the excessive accumulation of extracellular matrix (ECM) components. Current research highlights the crucial role of MΦ in activating fibroblasts in the development of fibrotic proc...

M. Słyszewska, A. Sadowska, D. Tobolski et al. · Theriogenology · 0 citations

Open access Sep 2026

Mare endometrosis induces endometrial proteome changes.

Endometrosis, characterized by excessive endometrial fibrosis, is a major reproductive disorder that impairs fertility and remains a significant challenge in equine breeding. The molecular mechanisms underlying equine endometrosis are not fully understood. This study investigated endometrial proteomic changes induced b...

Mariana Leal, Elisabete Silva, J. Alpoim-Moreira et al. · Theriogenology · 0 citations

Open access Aug 2026

The transcriptomic analysis of equine in vitro cultured fibroblasts derived from endometria with or without endometrosis.

The results showed that the transcriptomic profile of fibrotic fibroblasts was altered in comparison to non-fibrotic fibroblasts, which consequently could affect their function, and the gene profile of enzymes responsible for ECM remodelling was downregulated, indicating that the excessive ECM deposition in the fibroti...

A. Szóstek-Mioduchowska, A. Wójtowicz, A. Sadowska et al. · Reproductive Biology · 0 citations