Author

A. Szumera-Ciećkiewicz

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Open access Aug 2026

Tisa-cel and axi-cel CAR structure influences the development of resistance to CD19-CAR-T therapy.

It is shown that CAR structure is a critical determinant of CD19 loss in tumor B cells, and Mathematical modeling indicates that the failure of CD19-4-1BB-based CAR-T cells to eliminate CD19low cells, unlike CD28-based CARs, promotes the expansion of resistant populations.

Marta Krawczyk, K. Fidyt, Narcís Fernandez-Fuentes et al. · Leukemia · 0 citations