Pulmonary Penetration of Intravenous Rifabutin in Healthy Participants: A Multiple-Dose Pharmacokinetic Study.
BACKGROUND Carbapenem-resistant Acinetobacter baumannii causes severe respiratory infections with limited therapeutic options and high mortality. Although rifabutin exhibits potent activity against A. baumannii, oral administration results in low bioavailability and variable exposure. An intravenous formulation (BV100)...