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Author

A. Tonutti

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Open access Sep 2026

Immuno-based profiling of knee osteoarthritis patients identifies baseline characteristics associated with positive response to autologous platelet-rich plasma injection at one-year follow-up

Background Osteoarthritis (OA) is a degenerative musculoskeletal disease of multifactorial origin causing chronic disability, despite numerous treatment options for which there are no predictive biomarkers on the different endotypes. We aimed at defining a peripheral blood (PB) profile potentially predictive of early a...

V. Granata, A. Tonutti, V. Marrella et al. · 0 citations
Open access Aug 2026

High-sensitivity flow cytometry in rheumatoid arthritis shows that early B-cell subset depletion is linked to 5-year rituximab response, while failure to deplete B cells occurs early in subsequent poly-refractory disease.

OBJECTIVES To assess complete depletion of B-cell subsets using high-sensitivity flow cytometry (HSFC) across the therapeutic spectrum of rheumatoid arthritis (RA): from good initial rituximab (RTX) responders to poly-refractory RA (failed all biologic or targeted synthetic disease-modifying antirheumatic drug classes)...

A. Tonutti, K. Abacar, Paula David et al. · 0 citations

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