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Open access Sep 2026

Prognostic value of hormone receptor expression in patients with HR+/HER2− advanced BC treated with first-line ET+CDK4/6i: results from the multicentre observational, real-world PALMARES-2 study

Effectiveness of first-line ET plus CDK4/6i in patients with HR+/HER2− aBC worsens progressively with decreasing ERα expression, and PgR expression adds further prognostic discrimination, with low ERα and PgR expression identifying a subgroup of patients with particularly poor outcomes.

F. Ligorio, L. Provenzano, R. Caputo et al. · 0 citations
Open access Sep 2026

DCE-MRI and Mammography integrated radiomic analysis in triple negative ductal invasive breast cancer patients. Comparison between BRCA and not BRCA mutated patients: preliminary results

A combined radiomic model based on features extracted from DCE-MRI and mammographic images to discriminate the mutational status of BRCA genes in patients with TNBC reinforces the feasibility of radiomics to predict BRCA mutation in patients with TNBC.

A. Pecchi, Cecilia Beretta, Erica Balboni et al. · 0 citations
Review Open access Sep 2026

Clinical Implications of the Type and Genomic Location of Pathogenic BRCA1 and BRCA2 Variants in Hereditary Breast and Ovarian Cancer.

Germline pathogenic or likely pathogenic variants (P/LPVs) in BRCA1 and BRCA2 are major determinants of hereditary breast and ovarian cancer susceptibility. Although clinical management has traditionally relied on the presence of a BRCA1/BRCA2 alteration regardless of its specific characteristics, growing evidence sugg...

Emma Zattarin, C. Piombino, E. Tenedini et al. · 0 citations

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