Author

Atsushi Toyoda

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Open access Sep 2026

Cohesin prevents local mixing of condensed euchromatic domains in living human cells

The human genome is folded into chromatin loops by the cohesin complex, forming functional chromatin domains that underlie transcription and DNA replication/repair. However, how cohesin organizes these domains in living cells, especially in active euchromatin, remains elusive. Here, to address this question, we combine...

Masa A. Shimazoe, Shiori Iida, Katsuhiko Minami et al. · Nature Genetics · 12 citations

Open access Aug 2026

RPL41 stabilizes ribosome dynamics and supports long-protein homeostasis in mammals

Cryo-electron microscopy reveals a conserved role for RPL41 in maintaining ribosome dynamics and translational fidelity, indicating that RPL41 supports ribosome function and long-protein homeostasis in mammals.

Mina Hirata, Maho Fujino, Kazuya Ichihara et al. · Nucleic Acids Research · 0 citations