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Author

A. Tsankov

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Oct 2026

The Gα-interacting protein RGS4 in dorsal root ganglia maintains molecular and behavioral maladaptations in murine pain models.

Regulator of G protein signaling 4 (RGS4) is a Gα subunit-interacting protein that modulates the functional responses of various G protein-coupled receptors (GPCRs) and that is present in several components of the nociceptive circuitry. Here, we found that RGS4 in lumbar dorsal root ganglia (DRGs) is required for the m...

R. Serafini, B. Giotti, A. Luebbers et al. · 0 citations
Open access Aug 2026

Histone H3K27M variants determine myeloid subset dependencies and immune reprogramming in diffuse midline glioma.

Diffuse midline gliomas (DMGs) are highly aggressive, WHO grade 4 glial tumors that arise in midline central nervous system structures and are defined by K27M mutations in histone H3 genes. These K27M mutations shape intratumoral myeloid cell composition in DMG. In H3.1K27M DMGs, genetic ablation of monocyte recruitmen...

Montserrat Puigdelloses Vallcorba, K. Rawat, N. Soni et al. · 0 citations
Open access Sep 2026

Directing GABAergic neuronal identity from human iPSCs through developmental patterning.

It is shown that the chromatin state of the starting population constrains the neuronal identities specified by ASCL1 and DLX2, and it is demonstrated that the recurrent p.Tyr719∗ mutation disrupts interneuron maturation and subtype-associated transcriptional programs and impairs inhibitory synaptic transmission in hum...

Rui-Qi Hu, Linda L. Boshans, Yi-Ran Tao et al. · 0 citations
Open access Jul 2026

T cell differentiation drives programs of resistance to PD-1-mediated inhibition 2260353

Research into basic PD-1 biology, together with the clinical picture of cancer patients treated with PD-1 blockade, converge to emphasize that PD-1 engages complex signaling networks to support T cell homeostasis, differentiation and immune responses. However, there is a lack of comprehensive understanding in the...

Subhasree Sridhar, Woo-Seung Lee, E. Kanshin et al. · 0 citations
Open access Jul 2026

Cellular hallmarks and aging clock of the human lung parenchyma

Multiple cellular hallmarks of lung aging in human tissue are uncovered at single-cell and spatial resolution, including altered alveolar stemness, immune signaling, and macrophage respiration pathways, that may help assess lung biological age and disease risk.

Ke Xu, Grace S. Kim, A. Bhagwat et al. · 0 citations

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