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Author

A. Tyker

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Review Sep 2026

The emerging role of PDE4 inhibitors for the treatment of pulmonary fibrosis

ABSTRACT Introduction Nerandomilast, a phosphodiesterase-4B (PDE4B) preferential inhibitor, was approved in 2025 for the treatment of idiopathic pulmonary fibrosis (IPF) and progressive pulmonary fibrosis (PPF). PDE4 enzymes play a central role in regulating intracellular cyclic adenosine monophosphate (cAMP) and are h...

A. Tyker, N. Kuse, B. Pertzov et al. · 0 citations

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