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Author

A. V. van Spriel

2 papers indexed here

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Open access Aug 2026

TSPAN3 defines a distinct intracellular trafficking route to secretory multivesicular bodies

Extracellular vesicles (EVs) comprise molecularly diverse populations generated through multiple membrane-trafficking pathways, yet the intracellular basis of this heterogeneity remains poorly understood. Here, we identify the EV-associated tetraspanin TSPAN3 as a marker of a secretory multivesicular body (MVB) populat...

Jelle van den Bor, Misko Bobeldijk, C. A. Zala et al. · 0 citations
Open access Aug 2026

Multiple mechanisms regulate the nanoscale organization of PD-L1 at the cell surface

The immune checkpoint protein PD-L1 plays a pivotal role in tumor immune evasion by binding to PD-1 on immune cells, including T lymphocytes. While the expression and function of PD-L1 have been well studied, the importance of its spatial organization on the cell surface of tumor cells remains poorly understood. In thi...

Guus A. Franken, Abbey B. Arp, Dora Čerina et al. · 0 citations

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