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Hippocampal long-term potentiation (LTP) can persist in the chronic epileptic state, but the mechanisms supporting this residual plasticity remain poorly understood. In particular, it is unclear whether LTP retains canonical N-methyl-D-aspartate receptor (NMDAR) dependence or shifts to alternative induction mechanisms....
Malformations of cortical development frequently underlie drug-resistant epilepsy, yet little is known about how malformed cortical networks terminate epileptiform activity. In acute cortical slices from juvenile male Wistar rats with a focal freeze lesion, we compared the microgyrus and paramicrogyral zone during low-...
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