Nucleosomes with their associated modifications organize and regulate the genome. It is unclear how this is integrated with the requirement of replication and transcription to access the DNA template without jeopardizing chromatin function. Here, we reveal a unified requirement for the histone chaperone FACT in mediati...
R. C. M. Frater, Rikke Rejnholdt Jensen, Joaquim Ollé López et al.· Molecules and Cells· 0 citations
A single-cell multiomics atlas of the human pancreas is presented, profiling over four million cells and nuclei from 57 donors across fetal development, adult homeostasis, and type 2 diabetes.
E. Mereu, Diego Balboa, J. Liebig et al.· Cell Metabolism· 1 citation
Utilizing key developmental cues and refining their orchestrating role in degeneration represents a promising strategy for understanding and treating intervertebral disc (IVD) degeneration, a major cause of chronic lower back pain. Here, we focus on notochordal cells (NCs), which originate from the embryonic notochord...
Deepani W. Poramba-Liyanage, Xiao-Le Tong, F. Riemers et al.· Bone Research· 0 citations
SCISSOR (Single-Cell Inference of Structural States of Ribosomes), a strategy that infers global translation activity in individual cells from the differential protection of ribosomal RNA against nuclease digestion, is introduced, establishing a framework for studying global translation control at single-cell resolutio...
Euan Joly-Smith, Michael VanInsberghe, Kseniia Sarieva et al.· bioRxiv· 0 citations
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