Molecules and Cells
S. Modaresi, Lei-Lei Zhang, A. Saei et al.
· 0 citations
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Open access
Aug 2026
Loss of the mitochondrial SAM transporter reveals a lipoylation-dependent metabolic vulnerability in the postnatal heart
The neonatal heart experiences rapid metabolic growth after birth to meet increasing energetic and biosynthetic demands. How mitochondrial cofactor availability limits this transition remains unclear. Here, we demonstrate that mitochondrial S-adenosylmethionine (mitoSAM) import through SLC25A26 becomes limiting shortly...
Anastasia Rumyantseva, Trevor S. Tippetts, Alissa Wilhalm et al.
· Science Advances · 1 citation