Abstract Background Animal studies show that stress triggers immune dysregulation, leading to elevated levels of pro-inflammatory cytokines and microglial activation. This response is linked to excessive synaptic pruning and reduced synaptic density, potentially raising vulnerability to mental illness. In humans, child...
M. Zilberman, E. Vieira, C. Côté et al.· International Journal of Neu...· 0 citations
Abstract Background Over four decades of research have linked synaptic pathology to a broad range of brain disorders. Postmortem studies in conditions like psychosis spectrum disorders, Parkinson’s and Alzheimer’s Disease (AD) show changes in synaptic integrity but are confounded by factors such as illness duration or...
G. Mirfallah, C. Schifani, D. Shateri et al.· International Journal of Neu...· 0 citations
Older adults with treatment-resistant depression are at significant risk for cognitive impairment. However, the relationship between treatment response and cognitive function in this population is not well-established. We examined neural correlates of executive and memory function, and their relationship with remission...
Peter Zhukovsky, M. Butters, H. Lavretsky et al.· Nature Communications· 0 citations
Brain age measures reflect cognitive, but not antidepressant, outcomes following rTMS in LLD, and Structural-MRI based centile scores may serve as biomarkers of cognitive function and predictors of rTMS-related cognitive improvement in individuals with LLD.
Dora Shi, Tesam Ahmed, Katharina Göke et al.· Biological Psychiatry: Cogni...· 0 citations
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