Alex von Kriegsheim

ER-liquid condensate contacts sequester FAM134B/C and RhoA to govern cell morphology.

Endoplasmic reticulum (ER)-phagy receptors have elusive physiological functions beyond ER remodeling. To gain insight into these, we screen for cytoplasmic interactors of well-known receptors in mouse pancreatic ductal adenocarcinoma cells. Our data subsequently reveal a non-canonical action of PRKAR1A, a subunit of pr...

Dual inhibition of SGLT 1 and 2 by sotagliflozin alleviates intracellular sodium overload and improves cardiometabolic remodelling in uraemic cardiomyopathy.

AIMS Chronic kidney disease (CKD) is associated with uraemic cardiomyopathy characterised by early metabolic dysfunction. Elevated myocardial intracellular sodium (Naᵢ) has emerged as a driver of cardiometabolic remodelling, however, its role in CKD and therapeutic modulation remains unclear. We investigated whether du...

mTORC2 stabilizes HIF-1β to coordinate metabolic adaptation in lung cancer

Changes in metabolomic profile in dogs with hepatic encephalopathy secondary to congenital portosystemic shunt suggests mitochondrial homeostasis disturbances.

Objective To identify specific metabolomic changes in dogs showing signs of hepatic encephalopathy (HE) compared to those not showing obvious neurological signs and to follow these changes following medical treatment. Methods In this prospective observational study, we recruited 10 client-owned dogs diagnosed with co...

Intestinal bacteria hijack an evolutionarily conserved epithelial repair signal

Hypoxanthine is a potent promoter of epithelial cell repair in both gut and skin across the phylogenetic tree including humans, mice, zebrafish, and fruit flies and promotes similar ATP production and cellular proliferation in eukaryotic and microbial recipients.

The most common epilepsy-causing mutation in EEF1A2 (E122K) perturbs the translation of specific transcripts but not the rate of global protein synthesis

P perturbation of expression of a subset of genes, with a slight skew towards downregulation, in both the translatomic and proteomic datasets indicated a down regulation of proteins involved in synaptic function in both the translatomic and proteomic datasets.